Beforehand I thank
those who can correct mistakes in grammar!!!
What itself represents
tubercular process?
Do not hurry up to tell, that the science knows the
answer to this question!!! The person and so has made many errors in
haste. And failure in the decision of a problem of a tuberculosis just can and
consists that something is incorrect we have defined, what we go not in the
correct way?
I want to introduce well-known expression J.J.Thomson: From all services which can be rendered to a
science, introduction of new ideas is the most important. And the
second: Also to the most
important for a science good turn is not only introduction of new ideas, but
also comprehension of perversity old . And we should remember it always, even in that case when the person
something considers unshakable.
The page about a tuberculosis on a site Medical
information network begins with expression from B.Puhlika's monography
Tuberculosis: State of emergency?: series
of experts WHO specify, that that hour
when the tuberculosis will be practically incurable disease approaches.... He
is famous expert in a phthisiology.
In 1993 World Health Organization has developed the plan
which has been designed for drop within a decade twice mortalities from this
communicable disease which is carrying away 2 million of life annually. However,
as mark T. Brjuer and J. Haman, the Harward explorers, which have studied last
epidemiological data, in many countries of the world the position with tuberculosis for last
10 years practically has not improved. The morbidity in
equatorial and austral parts of Africa and in some countries of the
And is farther Global strategy of struggle against
tuberculosis requires essential revision,
do conclusions the Harward scientists who have published them in "American
Journal of Epidemiology", Global efforts on struggle against
tuberculosis yet have not brought expected success. It the conclusion
of the recognized experts in the attitude of program DOTS accepted in 1993.
In medical
mass-media today is enough of information on a worsening situation on morbidity
of tuberculosis.
More recently it seemed that illness has been defeated. But she again reappears, moreover with more complicated and malignant
current. The tuberculosis as was considered earlier is an illness hungry and
cold, and today to this disease are subjected and the provided layers of the
population.
Director of Institute of a phthisiology and pulmonology
of a name of Yanovsky AMS of Ukraine, the main phthisiatrician and the main
lung specialist of Ministry of Health of Ukraine, academician AMS, Dr. of
medical sciences, professor Jury Feshchenko that writes in article the
Situation with a tuberculosis in Ukraine: Under
forecasts of World Health Organization (WHO), within the next decade on our
planet is supposed originating 90 million cases of a tuberculosis, and the
majority of them in an age-grade from 20 till 49 years, i.e. in the most productive
term of life. From falling ill
people about 30 million can die in the same decade if the attitude to this
global problem will not be radically changed. Magazine the Doctor, 42002.
The tuberculosis cannot be won, but to supervise
him is in our forces, is A.N.Ordy, the head of department of public health
services of Donetsk regional state administration at a seminar Experience and
the first results of implantation of strategy of struggle against a
tuberculosis, the recommended World Health Organization, in Donetsk range has
told. On January, 21-22, 2002, Donetsk, Ukraine.
I categorically
disagree with that the tuberculosis cannot be won. It can be made the
nearest years. And this application is proved. I want to warn the reader, that
all new about what it will be told, is author's ideas. And while they will not
be accepted by a society, they will remain private statements.
The establishment for the given application is results
of the carried out researches. And the most basic about what it is necessary to
tell is that analysis is based an official actual stuff which is received in a phthisiology on
present time and which experts use. Only conclusions on this stuff are done
completely others.
Experience of research work in an
oncology (and in other sciences) has allowed to draw a conclusion that for
today in the attitude of many diseases including in a phthisiology, enough of
various experiences, experiments, and other researches including clinical is
carried already out. I.e. is quite enough actual stuff to understand the given
problem.
So, as all it is recognized, that the
tuberculosis is a contagion, and that the exciter of
tubercular process is a micobacterium. This theory is
unshakable. Here again there is a lawful question and what here
still it is possible to add new if the etiopathogenesis of a tuberculosis is
completely known? And the second question and if
all is known then why it is impossible will cope with tuberculosis? Than is more
applied efforts, that the tuberculosis becomes more malignant.
Let's recollect the past. Scientist B.V.Norejko, chief
faculty of a phthisiology and pulmonology of Donetsk state medical university
of a name of M.Gorkogo, d.m.s., the professor in the monography writes
Immunological aspects of a tuberculosis: Looking
back back, it is possible to tell with confidence, that in up to antibacterial
an era the tuberculosis represented smaller threat to mankind, than now . During all antibacterial era we
meaningly damaged the infection of
tuberculosis contamination all power of
antibacterial therapy. Each new stage of damage mycobacterias with use
of new antibacterial preparations was accompanied more and more by radical
changes of biological, antigenic and structural properties of atypical variants
mycobacterias Spontaneous
flow of a tuberculosis in the past proceeded not under such horrifying script
as it descends now more often. Comes a complete limen of antibacterial therapy.
Application of antibacterial therapy began at the end
of 40th years. Also what happened further? Hoped, that offensive to a
micobacterium should result in a victory over tuberculosis. And in a result we
have received inverse result. WHY?
The answer is not difficult, apparently, we do something not so. Only it is
difficult to admit it to itself. So, for example, the tuberculosis began to
show forms at which micobacteria even with use of the newest methods of
research are not find. But we are adhered to an official etiopathogenesis. And
consequently we speak (justifying the failures), that we can not find a
micobacterium as we have insufficient means for this purpose. Micobacteria in an organism are not find, and we speak, that the exciter
- she. How so ? In fact
this fact goes in a contradiction with the recognized hypothesis about the
exciter of a tuberculosis - micobacteria. The more we attack a micobacterium, the more she is
inaccessible. The impression is frameed, that someone or
something, her protecting. And can it so?
Appropriateness there is a question: and the
micobacterium can plays in the nature other role; than what to her is
determined in phthisiology? Only in that case a developed situation in
the attitude of tuberculosis becomes more explained.
All know that the micobacterium (Kokh bacillus)
belongs to a saprophytes class. In biology is the known fact, that saprophytes in the nature act on a mineralization (recycling) dead organic
substances, i.e. not alive. Not clear, why the science then carries a
micobacterium which amazes alive, to saprophytes?
So why we declare, what the micobacterium the
exciter of tuberculosis? In fact in this case the medicine denies biologists.
The science should not suppose such inverse views. Till now is not
found any substances with which the micobacterium would amaze alive frames.
Then than and how she amazes alive frames?..
Micobacteria by which the role of the exciter of a tuberculosis today ascribe
to, cannot by the nature (according to a biological role) to amaze alive
organic bonds. And it means that they cannot be the exciter of
tubercular process.
Many will apprehend this
application in bayonets. Very much I beg, DO NOT HURRY UP. Some
reviewers and opponents cannot agree with an idea on that yet, that the
micobacterium is not the exciter. With a new view it was always difficult to
agree. Let's spend experiments.
For example, that writes in B.V.Norejko's monography:
Scientists-bacteriologists try to frame optimum mediums on which micobacteria
quickly grow. I do not know precisely, what pathes go researches, but think,
what not absolutely correct (and it
is recognized by the leading scientist). It turned out, that it is necessary to make crushing an animal tissue, and to use products of a
necrobiosis as the additive to a medium; for intensifying mitotic activity of
culture of bacteria of tuberculosis. Abroad scientists
yet have not solved this phenomenon. And in fact it is valid; cultivation of
micobacteria is a problem which many try to solve. Why foreign scientists (and not only) cannot
understand why at addition of the dead crushed tissue mitotic activity is
accelerated? It in fact is not
stacked with the theory about a micobacterium, as about the exciter.
And in fact the answer has been given just that. Words of illustrious scientist
eloquently confirm a conclusion that micobacteria are not
exciter of a tuberculosis, as they mineralize dead organic substances, instead of alive. And it denies a
contagious role of a micobacterium.
Why the erroneous and inverse opinion
was framed? But only because incorrect experiments were put, and in
B.V.Norejko's assumption appeared the rights. Explorers raised micobacteria on
alive nutrient optimum mediums. And as soon as began to add products of a
necrobiosis (dead organic bonds) then micobacteria changed, revived, and their
mitotic activity strengthened. It just eloquently speaks about a correct
conclusion of biologists in definition of a role of saprophytes (including
micobacteria) in the nature.
Thus, the
first conclusion which managed to be made after carrying out of analysis: - micobacteria are not the exciter of a tuberculosis, and tubercular
process is not a contagion. This hypothesis yet is not accepted
by scientists - phthisiatricians. Though existing results in a phthisiology
answer an offered hypothesis than official, more.
R.Koha's
postulates (interpretation of official medicine) which I bring from article
Phthisiology: a becoming and development, directions and priorities (published
in magazine the DOCTOR,
1. At any form of a tuberculosis is discover the same exciter -
bacillus Kokh whom now name a micobacterium of a tuberculosis.
2. The
exciter entered into an organism of a
laboratory animal, produces tuberculosis.
3. At any
other disease such exciter is not discover.
Earlier above postulates of the great explorer I did
not reflect, as also considered their firm. And this case has turned all. It
wanted to understand, in than and as I rebut these postulates.
Also it was possible to find those original postulates
which R.Koh in 1882 has reported at session of the
- The
microorganism should be revealed in all cases of the given disease,
and all signs of illness should speak number and allocation of microbes;
- The microorganism should be received
in culture in the pure state;
- At infectioncultivated microorganism of the experimental animal, the last should
have conforming disease;
- The
microorganism should be received from a sick animal.
And, as you can see, R.Koha's postulates have changed
not on my fault. He has declared four demands, and in due course one has
disappeared and remained only three postulates. R.Koh did not declare about the exciter, He spoke only
about microorganism. Why one postulate
has disappeared and, as a matter of fact, they have changed? The answer is not
present.
Why subsequently have blindly decided, what
the micobacterium is the exciter? Real proofs of it in a phthisiology does not
exist! Unless cases when the micobacterium
is not excreted are not observed today? Unless cases of convalescence are
observed at absence of antibacterial treatment? Unless everyone are exposed to
disease by a tuberculosis at infestation by a micobacterium? Unless, at
infestation by bacteria organisms are absolutely amazed? And such questions
which put the recognized theory under doubt, arises much. And in fact at semination a micobacterium, unique from
so-called contagious bacteria, are amazed only less than 50% of organisms. And
thus it is impossible to forget that except for semination micobacteria we necessarily variate also
natural normal conditions to experimental organisms, i.e. we subject
long influence of extreme loads.
Presence of a micobacterium at the patient
(as they say in R.Koha's demands) yet does not speak that she is the exciter;
therefore he names their microorganism. And the second, semination micobacteria
of an organism and originating thus of a tuberculosis yet does not speak that
the micobacterium is the exciter of a tuberculosis. In an organism it
is possible to cause disease by introduction in him of excessive quantity, for
example, Hormonums. We do not declare that they carry out a negative role in an
organism and are "exciter" of disease.
On the contrary, we speak about beneficial function of Hormonums for an
organism.
R.Koha's postulates are precisely bound with
a new hypothesis. At tubercular process there should be a
micobacterium in an organism. And what for she there appears and what
role thus executes? Still it is necessary to answer this
question. And the most basic is that by quantity of micobacteria it is possible
to judge character (gravity) of illness.
B.V.Norejko's very interesting statement, in article
Immunological aspects of a phthisiology: When in
Imagine a
monocyte, in which protoplasm the colony of the micobacteria develop which are
taking place in the biological attitude (in symbiose) with a monocyte. The
monocyte has for some reason allowed to lodge to the exciter of a tuberculosis
in the body? The symbiose presenting peaceful co-existence of a latent
tubercular infection contamination with the most important representative of
cellular immunodefence - a monocyte, testifies to that, What is the concepts as
a latent infection, infection (a bend tuberculine sensitivities) without development of
the clinical form of a tuberculosis, it it is necessary to survey not only at a
level of internal organs, but also at a
cellular level. It is spoken by the recognized scientist. I disagree only with
last offer. And the immune system
can actually protects a micobacterium from aggressive influences on her on the
part of harmful substance? The micobacterium can carries out beneficial
function for an organism? And this
process, is sure, descends is in a reality. To an extreme measure, it managed
to be assumed on the establishment of the carried out research of stuffs of a
phthisiology.
Presence at an organism of a micobacterium can be a
fine marker for confirmation, of that in an organism has arisen and educes
tubercular process. Apparently, micobacteria in an organism carry out the
certain positive role about which we shall talk further. Do not hurry up to deny and reject!!! And so in
medicine many errors are made.
I admit, you agree, that micobacteria are not the exciter of tuberculosis, and the
tuberculosis is not infectious
process. It can be assumed. Then there is a lawful question
and what itself represents this disease which sometimes name tsar of diseases?
To draw a
conclusion that a tuberculosis a NOT
infectious disease, was not difficult. Was much more
intricate to understand and reply, what itself represents an etiopathogenesis
of the given disease?
To answer this question it was necessary to
investigate and analyse of a stuff and not only a phthisiology, but also on
many directions, both in medicine, and in other sciences. In a phthisiology
appeared not enough of that stuff, the basic role was given only to interaction
of a micobacterium with an organism, as infestant, and to an influence on her
of various materials. I.e. showed one-sided.
It would be desirable to pay attention to the
following question - and why
explorers in spite of the fact that there is enough stuff, could not do a
similar conclusion in the attitude of tuberculosis?
Let
explorers do not take offence at me. I do not want them offending. They have made much enough, and their work
has allowed me to present new conclusions. I want to express for it to them
gratitude! But it would be desirable to tell simultaneously,
that by the basic error in researches there was that all researches were
carried out one-sidedly, and only in relation to a micobacterium, as to the
exciter of a tuberculosis. They could
not depart for
frameworks of the official theory. And unless it is possible to carry
out one-sided researches in a science? But we not always act how we think.
For example, all of you know, and not once meet to
cases of convalescence of tubercular patients without application of
antimicobacterial preparations. They accepted those or other Adepses, or kept a
normal diet. Such cases remain in
medicine in the category of surprising and inexplicable phenomena. How in
this case goes a process of an adhesion and why in this case micobacteria stop
the negative action?
Accordingly, to answer this question an explorers the
conforming experiments have been put. And as a result the following conclusion
was born: - Adepses not do antibacterial influence; therefore
treatment by them is noneffective and impossible. But in fact at
certain cases of Adepses-therapy convalescence were observed? And they till now have
not found an explanation. Why we, seeing to,
what there comes real convalescence, reject him? If Adepses do not influence
micobacteria how the organism recovers, in fact it is a reality? We do
not trust that we see own eyes. And in this situation the
reality obviously contradicts the recognized theory of tuberculosis, as
infectious disease.
At carrying out of researches in the attitude of a
tuberculosis at all it was not given attention to other processes which
have no the manifestative attitude to micobacteria. For example,
practically researches on a
defatting of an organism were not carried out. Though finally the
organism of the patient with development of tubercular disease is degreased.
And so, originally the answer has been found not in a phthisiology, and only
then he has found acknowledgement in stuffs of a phthisiology.
Explorers
have done fine work. Her result became conclusions that the tuberculosis is
disease of cold and hungry peoples. And these conclusions were very true - the
tuberculosis arises in an organism which is subject to a starvation, to a cold
and dampness. I.e. to long influence of extreme conditions. But on it all also
has terminated, further explorers passed to a micobacterium. It and became an error.
Let's analyse these conclusions from the point of view
of physical and chemical processes. These are extreme conditions. Also I shall
not tell anything new when I shall tell that in extreme
conditions in an organism the increased charge of Adepses and first of all on
the energy purposes begins. Thus, as a rule, the
charge of Adepses in an organism exceeds his entering from the outside. I.e. the
organism is degreased.
Thus, the
tuberculosis can arise in an organism when the organism is exposed to long
influence of extreme conditions. Thus the basic condition should be kept: use
of Adepses in an organism should exceed their entering from the outside. In
other words, this process can be named AS process of
organism defatting. This conclusion does not contradict also
to an official hypothesis.
And in what it can result further? As a rule,
practically in a basis of all diseases there is one obligatory condition is a
transformation of an able-bodied cell in pathological. I.e. any disease results
finally in transformation of an able-bodied cell into the sick cell. And it
means, that there come irreciprocal processes.
And in the standard etiopathogenesis this rule have
forgotten. Researches on transformation of able-bodied cells in pathological
were not led. And if they were led, were
surveyed only from the point of view of transformation of able-bodied frames in
pathological under influence of micobacteria. If in all an
organism there is an excess of the use of Adepses over their entering in an
organism from the outside nobody will doubt that there is a process of
defatting and first of all in the certain cells.
And if in
a basis of diseases pathological transformation of cells give also we process
of a defatting of cells which should lays shall consider or can result in a
pathology. Thus we should have precisely in view of, that is necessary to
survey only that defatting of cellular structure which can result in
transformation of an able-bodied cell to pathological. I think, that with it
all will agree.
What cells can be exposed to a pathological defatting?
Conversation is conducted about Adepses and consequently we shall start with
lipoblasts. Lipoblasts can have in a normal homeostasis practically only an
capsule in which there are no Adepses. It is not a morbid condition. Lipoblasts
can how to accumulate Adepses so them and to give. They act a fat depo of an
organism. And it means, that process of
a defatting of these cells cannot transform a lipoblast from able-bodied in
pathological. Hence, these cells cannot participate in this
process. It is necessary to note, that we do not speak about a pathological
obesity at which lipoblasts can turn from able-bodied in pathological.
The following phylum of cells are lipoblasts. In these
cells the excessive quantity of Adepses results in an obesity that can result
in a pathology. And loss of Adepses by such cells will be not-only not-pathological, but on the contrary, improving. And it means, that for lipoblasts process of a defatting will not be
pathological; also that the defatting cannot result in a pathology.
The following phylum of cells are lipoblasts. In these
cells the excessive quantity of Adepses results in an obesity that can result
in a pathology. And loss of Adepses by such cells will be not-only not-pathological, but on the contrary, improving. And it means, that for lipoblasts process of a defatting will not be
pathological; also that the defatting cannot result in a pathology.
It is known, that synthetic cells contain in cytoplasm
additional lipide, i.e. fatty corpuscles (Osmiophylny lamellar corpuscles) which they use for
synthesis of those or other materials for needs of an organism.
And now
let's consider functional activity of such synthetic cells in normal conditions
and in extreme.
In normal conditions fatty corpuscles of these cells
are constantly used on synthesis of new materials. And it is natural, that in these fatty corpuscles Adepses should enter constantly. At use the
quantitative composition of Adepses should be replenished constantly. We know that in normal
conditions there is an entering in an organism of necessary materials,
including Adepses. Thus, synthetic
cells are characterized by a
Certainly, that in real conditions, this
Now we shall consider conditions when the organism is
exposed to long extreme loads. In these conditions there is an excess of use of
Adepses over entering of them from the outside. And it means that synthetic
cells continue to use the fatty corpuscles on synthesis of materials, and
replenishment of quantitative composition
of Adepses does not descend.
In a result there is a process of a defatting of these
cells. Is known, that any changes can have certain character in this or that
side. I.e. in this case process of a defatting should not exceed any certain
minimal size. In medicine it is known, that in cases when any changes exceed acceptance limits further
there are irreversible processes.
I.e. it turns out, that in a case when the defatting
of cells can exceed certain minimum level there
can step irreversible process. In this
case the cell cannot fill normal quantitative composition even if to such cell
necessary Adepses will enter at the certain good situation. I.e. in such cells process of an irreversible defatting (PID) begins.
Thus, in cases when the organism is exposed to long
influence of extreme conditions at excess Adepses of use over their arrival
from the outside; in those or other synthetic cells process of defatting begins, which can
become under certain conditions irreversible, and result in transformation of an able-bodied cell
in pathological.
Process of an
irreversible defatting (PID) of cellular structure of an organism, it is a tubercular process. From the moment of appearance in an
organism of a cell which has passed on a route an irreversible defatting, and
there is tuberculosis. Or it is
possible to tell in another way - process of
irreversible-loss of Adepses (PILA).
We admit, opponents will tell, that is possible to
agree with this hypothesis. But then there is a lawful question - and what
attitude micobacteria to tubercular process have, and why they are found in patients? Though is impossible to forget, that micobacteria also can be found in
able-bodied persons, and thus from them 5-10 % fall ill only.
It is
necessary to note, that tubercular process is very complex process. Let's
consider all his stages.
First, as it was already marked, tubercular process begins from the moment of
appearance in an organism of a cell or bunch of cells in which began process of
an irreversible defatting. This
basic infringement at tuberculosis.
Second,
when to tubercular cells Adepses start to arrive (they cannot acquire them), around of tubercular cells start to accumulate
excessive quantity of unused Adepses. Adepses to cells
of an organism I have address delivery. The accumulation in
pericellular space of excessive Adepses represents already cancerogenic effect (factor). And since this moment the
mechanism of the further development of tuberculosis is identical to the
mechanism of originating and development oncologic diseases. It also explains
that oncologic diseases and on the contrary can accompany tuberculosis.
At the certain moment in pericellular medium about a
tubercular cell the critical quantity of cancerogenic Adepses accumulates;
after excess of this quantity, they flare up (process of noneffective
oxidation) begins. Burning of carcinogen results
in additional changes and for education around of a tubercular cell of new
frame a protective covering of pathological cell (PCPC). About it it is possible to familiarize
more in detail in stuffs on an oncology. As soon as PCPC it is formed completely such cell
practically is not exposed to influence of immunodefence and in to choronomic
influence badly gives. Disease passes in a chronic stage.
While any cell is alive (even what became
pathological), her certain gene will submit a signal that Adepses are necessary
for the given cell. And it is natural, that the organism will refer necessary
quantity of Adepses to such cell. For a normal cell it is will be normal
process.
And in a case, when the cell has passed the road an
irreversible defatting (i.e. in her tubercular process began), what then will descend? There will be a following - the cell
begins unable to accept Adepses, and the organism on a signal of a gene
continues them to deliver to a cell. In a result (it was already marked) there
is a cancerogenic factor. And only the
mors of a cell stops excessive entering Adepses, i.e. education of the
cancerogenic factor. Immune bodies can liquidate this cell.
But, at the certain stage they cannot liquidate her as the cell on the one hand
is weakened, and with another - has got PCPC. What to do in this case and how to liquidate a
tubercular cell?
And the nature has found the fine decision. The locus
with such cell (or group of cells) is isolated by an organism in separate
tubercular education - a tubercule (tuberculoma). In this education
the enter materials stop to. Cells which are in this education even at working
genes lose touch with an organism. In this education immune bodies also do not
arrive, that does not allow them to liquidate isolated educations.
As a
result of education of the isolated locus - the cancerogenic effect in a
tuberculous focus stop to. Once
again it is necessary to note, that the cancerogenic effect in some cases
results in originating oncologic diseases at tubercular patients, and on the
contrary.
Isolation of pathological frame in new education stops
originating cancerogenic effect. But in this education
pathological frames (process of fusion begins) slowly die-off and this locus
becomes the new pathological factor. Who will liquidate
consequences of such die-off in case to this education there can not arrive
immune frames? Such locuses today show increased malignant flows of tubercular process.
The carried out researches have allowed doing the
following conclusion: together with pathological frames in new
isolated educations mycobacterium arrive, which liquidate dead materials (a consequence a
tubercular cells of
necrosis). And in a result, contents of a tubercular hillock
are blasted without an inflammatory process. Apparently, that it is real role
which implement micobacterias.
That symbiose about which so explorers much speak.
That is why immune bodies do not destroy uninjured micobacteria. Micobacteria substitute immune frames in isolated
education, etc. In discussion with the academician, pathophysiologist, V.Mihnev has
arisen spores on symbiose of micobacterium and immunocytes. I protect my
hypothesis, and he - official hypothesis. So, he spoke that micobacteria
produce the certain materials which interfere with hinder for phagocytosis,
therefore and there is such picture. On what I have objected: - In
fact nobody, could not only see, but
also separate this material. Why then we so keep for this only the assumption,
and while a hypothesis anything the unproved for more than 100 years (attempts
was much)? And can it is valid, immune bodies protect
micobacteria, so they carry out positive function? He could not object to this
argument.
Confirmation
of the submitted hypothesis has been found in stuffs of a phthisiology. So, for
example, at the description of morphological changes it was spoken: - there
Are changes and in alveolocytes 2-nd
type. They are connected to rising a cellular penetrability. The volume of
mitochondrions sharply enlarged, their matrix is loosened, cristas are shortened. Ultrastructure
osmiophylny lamellar corpuscles (OLC) is broken: one osmiophylny corpuscles enlarged in the
dimensions, vacuolate; plates of others divided by wide light
interspaces; there is a thinning of plates; their flaking and destruction with
decrease inherent to them, high osmiophyly. Sometimes on place OLC the vacuole with the
residual osmiophylny plates is
formed - page 81-82 Functional morphology of lungs - V.V.Yerokhin, 1988. It
and is the description of process of a defatting of fatty (lipide)
corpuscles of a cell, so-called OLC. One alveolocytes follow the road of an IRREVERSIBLE
defatting, and others (with enlarged OLC) - incur
additional functions on synthesis of surfactant, instead
of tubercular cells. It the real proof of the submitted
hypothesis.
Explorers in this
cytologic picture observed a picture of process of an irreciprocal defatting of
cells; but their attention the dogma has distracted about the exciter of tuberculosis
micobacteria. Therefore they and could not explain "obvious".
Enough similar examples in a phthisiology.
Recently discussion with one known scientific
phthisiatrician has taken place; from the ethical point of view I do not name
his name. Me he been told: - Why I speak about alveolocytes which the organism
should isolate on a new hypothesis, if in tubercular hillocks of them it is not
found out. The basis of these educations is compounded with epithelial cells.
First I have been stumped. But then all has risen on
the places. And consequently, as on this objection there is an answer in stuffs
of a phthisiology. In opinion of explorers, the basic feature
of a specific inflammation at
tuberculosis will consist in original transformation of cellular
elements at which the main majority of them changes to epithelial cells, which
source of education both histogenic elements, and monocytes of a blood. This
quotation from V.V.Yerokhin's same monography, page 115. And accordingly, in
tubercule, for example, in lungs, epithelial
cells which were formed from alveolocytes will
prevail. Unless scientists not know it?
Thus, tubercular process is a process of an
irreversible defatting of cellular structure. There is tuberculosis
in an organism which in view of the certain causes is exposed to long extreme
conditions. Thus the use of Adepses in an organism exceeds their entering from
the outside. Micobacteria help an organism in liquidation
(processing) contents of the locuses which are isolated by an organism - a
tubercle and tubercular cells.
Absence of micobacteria or their liquidation
complicates terms of convalescence, results in appearance of more malignant
forms of tuberculosis. It happened because in the
isolated locuses decomposing a necrosis without participation of protective
forces of an organism begins; there is a specific purulent inflammation
(pathological fusion). Contents of such isolated locus
frequently break in an able-bodied tissue.
In
dependence on in what tissue and in what synthetic cells there comes process of
an irreversible defatting; we have
various forms a tubercular process of flow. By the way, it is
necessary to note, that Diabetum of the first type it is too
tubercular process in cells of a pancreas, but about it
conversation separate.
The submitted hypothesis of originating and
development of tuberculosis allows to answer many questions which are put in a
phthisiology. She allows to offer and a method of treatment (this question also
is made; it is necessary to note, that treatment of tuberculosis is very
specific). This hypothesis allows solving a problem of
tuberculosis.
To speak about treatment, all over again it is
necessary to prove an offered hypothesis. Today is possible to make new
experiments which will confirm this hypothesis. Is possible to model an
experimental tuberculosis without a lesion of an organism micobacteria. Today
it is possible to cure patients who are not helped any more by antibacterial
therapy, i.e. resistant patients. All specified experiments and conditions of
their carrying out are thought already over.
Today, and not only new preparations will be necessary
for treatment, but also for prophylaxis. Very considerably, in comparison with
today, the assortment of pharmaceutical preparations will increase. And, perhaps, for pharmaceutics of work it is necessary even more,
than for clinic.
As it became clear from an aforesaid stuff, analysis
in medicine began with oncologic diseases. Only after this work it was possible
to be defined and in the attitude with tuberculosis. Today two monographies,
about a cancer and tuberculosis are already issued. Researches and analysis are
finished; monographies about Diabetum and AIDS are prepared, but not issued.
And this volume of diseases refers to not in vain, though he very different. Them one initial binds the factor (infringement of an exchange of Adepses). On each
direction there is a science, but does not hurry up with a conclusion, and try
to recollect that these diseases have concomitant character. Also work above
the monography of "the Basis of the general pathological physiology is
ended. The official and sensible discussion so while has failed.
While all this stuff is not claimed. Very much I hope that the common sense will triumph. Unless
we do not want to solve a problem and
cancer, both tuberculosis, and Diabetum, and AIDS, and other diseases?
At all I do not speak, that it is completely right. All of us can be mistaken.
But I ask, let's look in a new fashion at
already cumulative actual stuff in medicine. If it is
necessary, let's put new experiments. Let's try solving a problem, instead of
to surrender before her. It is impossible to forget today that existing
conclusions on a cumulative stuff in medicine yet do not allow solving a
problem of many diseases. It speaks that in them there are some errors.
All of us know that at times firm things during the
certain moment can appear incorrect. For example, up to Kopernik all for a long
time trusted that the Sun rotates around of the Earth. However after his words,
today all of us know and convinced that all
very much the other way. And it is enough such examples.
Today
explorers do enormous work. In medicine there is enough stuff for correct conclusions,
but existing dogmas do not allow us to make them.
So, the tuberculosis is a not-infectious disease. The
micobacterium the NOT-Exciter of tuberculosis.
I want to
tell once again in summary, that told today is a new view on a problem. And he does
not apply for true in last instance. The stated hypothesis calls for the argued
discussion which, undoubtedly, will bear the fetuses.
Yours faithfully to the reader, the author, Peter
Savchenko.
02.2002.